研究業績
原著論文 * Corresponding author
- Konishi M, Kishi K, Morita R, Yamada A, Onuma TA and Nishida H* (2023, May).
Formation of the brain by stem cell divisions of large neuroblasts in Oikopleura dioica, a simple chordate.
Development Genes and Evolution. 233(1):35-47.
DOI:10.1007/s00227-022-04145-5 - Treen N*, Konishi S, Nishida H; Onuma TA and Sasakura Y (2023, Mar).
Zic-r.b controls cell numbers in Ciona embryos by activating CDKN1B.
Developmental Biology. 498: 26-34.
DOI:https://doi.org/10.1016/j.ydbio.2023.03.005 - Masunaga A*, Mansfield MJ, Tan Y, Liu AW, Bliznina A, Barzaghi P, Hodgetts TL, Ferrández‐Roldán A, Cañestro C, Onuma TA, Plessy C and Luscombe NM (2022, Nov).
The cosmopolitan appendicularian Oikopleura dioica reveals hidden genetic diversity around the globe.
Marine Biology. 169:157.
DOI:10.1007/s00227-022-04145-5 - Yamagishi M, Huang T, Hozumi A, Onuma TA, Sasakura Y and Ogasawara M* (2022, Nov). Differentiation of endostyle cells by Nkx2-1 and FoxE in the ascidian Ciona intestinalis type A: insights into shared gene regulation in glandular- and thyroid-equivalent elements of the chordate endostyle.
Cell and Tissue Research. 390(2):189-205.
DOI:10.1007/s00441-022-03679-w. - Nishida H*, Matsuo M, Kounishi S, Ohno N, Manni L, Nishino A and Onuma TA (2022, Jan).
Germline development during embryogenesis of the larvacean, Oikopleura dioica.
Developmental Biology. 481:188-200.
DOI:10.1016/j.ydbio.2021.10.009. - Onuma TA*, Nakanishi R, Sasakura Y and Ogasawara M* (2021, Sep).
Nkx2-1 and FoxE regionalize glandular (mucus-producing) and thyroid-equivalent traits in the endostyle of the chordate Oikopleura dioica.
Developmental Biology. 477:219-231.
DOI:10.1016/j.ydbio.2021.05.021. - Martí-Solans J, Godoy-Marín H, Diaz-Gracia M, Onuma TA, Hiroki Nishida H, Albalat R* and Cañestro C* (2021, Jun).
Massive gene loss and function shuffling in appendicularians stretch the boundaries of chordate Wnt family evolution.
Frontiers in Cell and Developmental Biology. 9:700827.
DOI:10.3389/fcell.2021.700827. - Morita R, Onuma TA, Manni L, Ohno N and Nishida H*. (2020, Nov)
Mouth opening is mediated by separation of dorsal and ventral daughter cells of the lip precursor cells in the larvacean, Oikopleura dioica.
Development Genes and Evolution. 230(5-6): 315-327.
DOI:10.1007/s00427-020-00667-4 - Wang K, Tomura R, Chen W, Kiyooka M, Ishizaki H, Tomooka A, Minakuchi Y, Seki M, Suzuki Y, Omotezako T, Suyama R, Luscombe NM, Dentec C, Lemaire P, Toyoda A, Nishida H and Onuma TA* (2020, Aug).
A genome database for a Japanese population of the larvacean Oikopleura dioica.
Development Growth and Differentiation. 62(6): 450-461.
DOI:10.1111/dgd.12689 - Matsuo M*, Onuma TA, Omotezako T and Nishida N (2020, Apr).
Protein phosphatase 2A is essential to maintain meiotic arrest, and to prevent Ca2+ burst at spawning and eventual parthenogenesis in the larvacean Oikopleura dioica.
Developmental Biology. 460(2): 155-163.
DOI:10.1016/j.ydbio.2019.12.005. - Onuma TA*, Hayashi M, Gyojya F, Kishi K, Wang K and Nishida H (2020, Feb).
A chordate species lacking Nodal utilizes calcium oscillation and Bmp for left-right patterning.
Proceedings of the National Academy of Sciences of the United States of America. 117(8): 4188-4198.
DOI:10.1073/pnas.1916858117.
・プレスリリース: https://resou.osaka-u.ac.jp/ja/research/2020/20200220_1
・日経産業新聞 (2/27/2020)、日経サイエンス (2020年6月号)で紹介記事。
・国内外の30以上のニュースサイトで紹介された (Yahooニュース、Exciteニュース、毎日新聞、北海道新聞、The Scientist Magagine, NewsBreakなど) - Dardaillon J, Dauga D, Simion P, Faure E, Onuma TA, DeBiasse M, Louis A, Nitta N, Naville M, Besnardeau L, Reeves W, Wang K, Fagotto M, Guéroult-Bellone M, Fujiwara S, Dumollard R, Veeman M, Volff JN, Roest Crollius H, Douzery E, Ryan J, Davidson B, Nishida H, Dantec C* and Lemaire P* (2020, Jan).
ANISEED 2019: 4D exploration of genetic data for an extended range of tunicates.
Nucleic Acids Research. 48(D1): D668-D675.
DOI:10.1093/nar/gkz955. - Iida A*, Arai HN, Someya Y, Inokuchi M, Onuma TA, Yokoi H, Suzuki T, Hondo E and Sano K (2019, Oct).
Mother-to-embryo vitellogenin transport in a viviparous teleost Xenotoca eiseni.
Proceedings of the National Academy of Sciences of the United States of America. 116 (44): 22359-22365.
DOI:10.1073/pnas.1913012116.
・プレスリリース:
http://www.kyoto-u.ac.jp/ja/research/research_results/2019/191008_1.html
https://www.sci.osaka-u.ac.jp/ja/topics/7930/
・ネットニュースの日本の研究.comや、テック・アイ技術情報研究所で紹介された。 - Yamada S#,Tanaka Y#, Imai KS, Saigou M, Onuma TA and Nishida N* (#equal contribution) (2019, Apr).
Wavy movements of epidermis monocilia drive the neurula rotation that determines left–right asymmetry in ascidian embryos.
Developmental Biology. 448(2): 173-182.
DOI:10.1016/j.ydbio.2018.07.023. - Onuma TA*, Matsuo M and Nishida H (2017, Sep).
Modified whole-mount in situ hybridisation and immunohistochemistry protocols without removal of the vitelline membrane in the appendicularian Oikopleura dioica.
Development Genes and Evolution. 227(5): 367-374.
DOI:10.1007/s00427-017-0588-1 - Kishi K*, Hayashi M, Onuma TA and Nishida H (2017, Aug.).
Patterning and morphogenesis of the intricate but stereotyped oikoplastic epidermis of the appendicularian, Oikopleura dioica.
Developmental Biology. 428(1): 245-257.
DOI:10.1016/j.ydbio.2017.06.008. - Wang K*, Dantec C, Lemaire P, Onuma TA and Nishida H (2017, Apr).
Genome-wide survey of miRNAs and their evolutionary history in the ascidian,
Halocynthia roretzi.
BMC Genomics. 18(1): 314.
DOI:10.1186/s12864-017-3707-5. - Omotezako T*, Matsuo M, Onuma TA and Nishida H (2017, Mar).
DNA interference-mediated screening of maternal factors in the chordate Oikopleura dioica.
Scientific Reports. 7: 44226.
DOI:10.1038/srep44226. - Onuma TA*, Isobe M and Nishida H (2017, Feb).
Internal and external morphology of adults of the appendicularian, Oikopleura dioica: An SEM study.
Cell and Tissue Research. 367(2):213-227.
DOI:10.1007/s00441-016-2524-5. - Kodama H, Miyata Y,Kuwajima M,Izuchi R,Kobayashi A, Gyoja F,Onuma TA,Kumano Gand Nishida H* (2016, Aug).
Redundant mechanisms are involved in suppression of default cell fates during embryonic mesenchyme and notochord induction in ascidians.
Developmental Biology. 416: 162-172.
DOI:10.1016/j.ydbio.2016.05.033. - Wang K*, Omotezako T, Kishi K, Nishida H and Onuma TA* (2015, June).
Maternal and zygotic transcriptomes in the appendicularian, Oikopleura dioica: Novel protein-encoding genes, intra-species sequence variations, and trans- spliced RNA leader.
Development Genes and Evolution. 225(3): 149-159.
DOI:10.1007/s00427-015-0502-7. - Omotezako T*, Onuma TA and Nishida H (2015, May).
DNA interference: DNA-induced gene silencing in the appendicularian Oikopleura dioica.
Proceedings of the Royal Society B. 282(1807): 20150435.
DOI:10.1098/rspb.2015.0435.
・プレスリリース:
https://www.sci.osaka-u.ac.jp/ja/wp-content/uploads/2015/05/270518release.pdf
・ 読売新聞 (6/1/2015)に紹介記事。
・ ネットニュースのThe Scientist Magagineで紹介された。 - Kishi K*, Onuma TA and Nishida H (2014, Nov.).
Long-distance cell migration during larval development in the appendicularian, Oikopleura
dioica.
Developmental Biology. 395(2): 299-306.
DOI:10.1016/j.ydbio.2014.09.006. - Omotezako T*, Nishino A, Onuma TA and Nishida H (2013, Jul.).
RNA interference in the appendicularian, Oikopleura dioica, reveals the function of the Brachyury gene.
Development Genes and Evolution. 223(4): 261-267.
DOI:10.1007/s00427-013-0438-8. - Onuma TA and Duan C* (2012, Jul.).
Duplicated Kiss1 receptor genes in zebrafish: Distinct gene expression patterns, different ligand selectivity, and a novel nuclear isoform with transactivating activity.
The FASEB Journal. 26: 2941-2950.
DOI:10.1096/fj.11-201095. - Onuma TA, Ding Y, Abraham E, Zohar Y, Ando H and Duan C* (2011, Aug.).
Regulation of temporal and spatial organization of newborn GnRH neurons by IGF signaling in zebrafish.
The Journal of Neuroscience. 31 (33): 11814-11824.
DOI:10.1523/JNEUROSCI.6804-10.2011.
* Olfactory Pathways—Advances in Research and Application: 2012 Edition (Q. Ashton Acton, Ed, Scholarly Edition)で紹介された - Onuma TA*, Makino K, Ando H, Ban M, Fukuwaka M, Azumaya T and Urano A (2010, Sep.).
Expression of GnRH genes is elevated in discrete brain loci of chum salmon before initiation of homing behavior and during spawning migration.
General and Comparative Endocrinology. 168: 356-368.
DOI:10.1016/j.ygcen.2010.05.001. - Onuma TA*#, Ban M*#, Makino K, Katsumata H, Hu W, Ando H, Fukuwaka M, Azumaya T and Urano A (#equal contribution) (2010, May).
Changes in gene expression for GH/PRL/SL family hormones in the pituitaries of homing chum salmon during ocean migration through upstream migration.
General and Comparative Endocrinology. 166: 537-548.
DOI:10.1016/j.ygcen.2010.01.015. - Onuma TA*, Makino K, Katsumata H, Beckman BR, Ban M, Ando H, Fukuwaka M, Azumaya T, Swanson P and Urano A (2010, Jan.).
Changes in the plasma levels of insulin-like growth factor-I from the onset of spawning migration through upstream migration in chum salmon.
General and Comparative Endocrinology. 165: 237-243.
DOI:10.1016/j.ygcen.2009.07.005. - Onuma TA*, MakinoK, Ban M, Ando H, Fukuwaka M, Azumaya T, Swanson P and Urano A (2009, Apr.).
Elevation of the plasma level of insulin-like growth factor-I with reproductive maturation prior to initiation of spawning migration of chum salmon.
Annals of the New York Academy of Sciences. 1163: 497-500.
DOI:10.1111/j.1749-6632.2008.03668.x. - Onuma TA*, Sato S, Katsumata H, Makino K, Hu W, Jodo A, Davis ND, Dickey JT, Ban M, Ando H, Fukuwaka M, Azumaya T, Swanson P and Urano A (2009, Jan.).
Activity of the pituitary-gonadal axis is increased prior to the onset of spawning migration of chum salmon.
The Journal of Experimental Biology. 212: 56-70.
DOI:10.1242/jeb.021352. - Hu W, Onuma T, Birukawa N, Abe M, Ito E, Chen Z and Urano A* (2008, Jun.).
Change of morphology and cytoskeletal protein gene expression during dibutyryl cAMP-induced differentiation in C6 glioma cells.
Cellular and Molecular Neurobiology. 28: 519-528.
DOI:10.1007/s10571-007-9229-y - Furukuma S, Onuma T, Swanson P, Luo Q, Koide N, Okada H, Urano A and Ando H* (2008, Jan.).
Stimulatory effects of insulin-like growth factor 1 on expression of gonadotropin subunit genes and release of follicle-stimulating hormone and luteinizing hormone in masu salmon pituitary cells at early gametogenesis.
Zoological Science. 25: 88-98.
DOI:10.2108/zsj.25.88.
・2008年度 日本動物学会論文賞 (Zoological Science Award 2009) - Onuma TA, Ando H, Koide N, Okada H and Urano A (2007, May).
Reproductive stage-related effects of salmon GnRH and sex steroid hormones on expression of genes encoding fushi tarazu factor 1 homolog and estrogen receptor a in masu salmon pituitary cells in vitro.
General and Comparative Endocrinology. 151: 64-72.
DOI:10.1016/j.ygcen.2007.02.024. - Onuma T*, Ando H, Koide N, Okada H and Urano A (2005, Sep).
Effects of salmon GnRH and sex steroid hormones on expression of genes encoding growth hormone/prolactin/somatolactin family hormones and a pituitary-specific transcription factor in masu salmon pituitary cells in vitro.
General and Comparative Endocrinology. 143: 129-141.
DOI:10.1016/j.ygcen.2005.03.003. - Onuma T*, Higa M, Ando H, Ban M and Urano A (2005, May).
Elevation of gene expression for salmon gonadotropin-releasing hormone in discrete brain loci of pre-spawning chum salmon during upstream migration.
Journal of Neurobiology. 63: 126-145.
DOI:10.1002/neu.20125. - Onuma T*, Higashi Y, Ando H, Ban M, Ueda H and Urano A (2003, Sep).
Year-to-year differences in plasma levels of steroid hormones in pre-spawning chum salmon.
General and Comparative Endocrinology. 133: 199-215.
DOI:10.1016/s0016-6480(03)00171-0. - Onuma T*, Kitahashi T, Taniyama S, Saito D, Ando H and Urano A (2003, Feb-Mar).
Changes in expression of genes encoding gonadotropin subunits and growth hormone/prolactin/somatolactin family hormones during final maturation and freshwater adaptation in pre-spawning chum salmon.
Endocrine. 20: 23-33.
DOI:10.1385/ENDO:20:1-2:23.
欧文総説・著書
- Onuma TA*, Nishida H (2022, Jan.).
Developmental biology of the larvacean Oikopleura dioica: Genome resources, functional screening, and imaging.
Development Growth and Differentiation. 64: 67-82.
DOI:10.1111/dgd.12769 - Makino K#, Onuma TA#, Kitahashi T, Ando H, Ban M, Urano A* (#equal contribution by two first authors) (2007, Jun.-Jul.).
Expression of hormone genes and osmoregulation in homing chum salmon: A minireview.
General and Comparative Endocrinology.152: 304-309.
DOI:10.1016/j.ygcen.2007.01.010
和文総説・その他
- 小沼健*, 森田遼 (2021).
オタマボヤの口形成にともなう外胚葉と内胚葉との接続.
比較内分泌学. 174: e0006. - 小沼健*, 戸村亮 (2021).
日本系オタマボヤのゲノムデータベースとY特異的領域.
比較内分泌学. 172: 28-30. - 小沼健*, 松尾正樹 (2020).
オタマボヤ未受精卵の減数分裂停止をになう脱リン酸化酵素PP2Aの役割.
比較内分泌学. 171: 117-118.
DOI:10.5983/nl2008jsce.46.117 - 小沼健* (2020).
体の左右はどのようにできるのか？-オタマボヤの左右非対称性を探る.
academist Journal. - 小沼健* (2020).
特殊な現象の壁を越える 〜「最も単純な体の脊索動物」オタマボヤから見出した新しい遺伝子阻害現象 (DNAi)と左右非対称形成〜
比較内分泌学. 170: 85-87.
DOI:10.5983/nl2008jsce.46.85_2 - 小沼健*, 松尾正樹 (2019).
母性因子の大規模な母性因子の大規模な機能的スクリーニングを可能にする新しい脊索動物.
Medical Science Digest. 6: 42-43. - 小沼健*, 松尾正樹, 西田宏記 (2018).
オタマボヤの発生学を開拓する:「単純な体の脊索動物」という個性を活かす試み.
実験医学. 36 (6): 1021-1025. - 小沼健*, 塚田かすみ, 西田宏記 (2018).
二本鎖DNAによる新規の遺伝子ノックダウン現象 (DNAi): ガイド鎖と核酸分解酵素
Argonauteからそのしくみに迫る.
日本応用酵素協会誌. 52: 11-18. J-GLOBAL ID：201802234019413927 - 松尾正樹*, 表迫竜也, 小沼健, 西田宏記 (2017).
脊索動物ワカレオタマボヤを用いたDNAiによる母性因子の機能的スクリーニング.
比較内分泌学. 162: 136-137.
DOI:10.5983/nl2008jsce.43.136 - 表迫竜也*, 西田宏記, 小沼健 (2016).
脊索動物ワカレオタマボヤにおける2つの遺伝子サイレンシング機構: RNA
interferenceとDNA interference.
比較内分泌学. 157: 5-7.
DOI:10.5983/nl2008jsce.42.5 - 岸香苗*, 西田宏記, 小沼健 (2016).
実験動物紹介: ワカレオタマボヤ.
比較内分泌学. 157: 1-4.
DOI:10.5983/nl2008jsce.42.2 - 小沼健* (2013)
ゼブラフィッシュにおけるKiss1受容体の重複遺伝子が示す「発現とリガンド選択
性の多様性」および「転写促進活性をもつ核局在バリアントの存在」.
比較内分泌学. 148: 48-51.
DOI:10.5983/nl2008jsce.39.48 - 小沼健* (2011).
IGFシグナルはゼブラフィッシュ初期胚におけるGnRHニューロンの局在に必須である.
比較内分泌学. 143: 211-214.
DOI:10.5983/nl2008jsce.39.48 - 小沼健* (2010).
シロザケの産卵回遊の開始および淡水適応に先立つ成長ホルモン／プロラクチン／ソマトラクチンファミリー遺伝子の発現変動.
比較内分泌学. 138: 211-214.
DOI:10.5983/nl2008jsce.36.211 - 安東宏徳*, 小沼健, 浦野明央 (2009).
GnRHに対する反応性の分子制御とサケの産卵回遊.
比較内分泌学. 132: 7-23.
DOI:10.5983/nl2008jsce.35.7 - 小沼健*, 安東宏徳, 浦野明央 (2006)
産卵回遊の分子内分泌学的基盤.
海洋と生物. 28 (1): 31-41.
